The Church and former monastery of Santo Domingo de Guzmán (Spanish: Templo de Santo Domingo de Guzmán) is a Baroque ecclesiastical building complex. The complex includes a substantial sanctuary and an extensive system of courtyards, cloisters and rooms that formerly constituted the monastery.
As its name implies, the church and monastery were founded by the Dominican Order. Begun in 1575, they were constructed over a period of 200 years, between the 16th and 18th centuries. The monastery was active from 1608 to 1857. In the period of the revolutionary wars, the buildings were turned over to military use, and from 1866 to 1902 they served as a barracks. The church was restored to religious use in 1938, but the monastery was made available to the Universidad Autónoma Benito Juárez de Oaxaca. In 1972 it became a regional museum, and in 1993 the decision was taken to undertake a full restoration. This was completed in 1999. It is an exceptional example of conservation architecture. The architect responsible was Juan Urquiaga.
The church has also been fully restored. Its highly decorated interior includes use of more than 60,000 sheets of 23.5-karat gold leaf.